Contact:
  
           Kohlgasse 28/2/22
           A 1050-Wien
           Tel.: +43-650-8627835
           email: christoph.campregher (at) meduniwien.ac.at
           Nationality: Austrian
                     

Education:

Career History:

Research Activities:

  PUBLICATIONS:            

• Honeder C, Campregher C, Zens B, Scharl T, Gasche C. "Improvement of replication fidelity by certain mesalazine derivatives"Int J Oncol. 2012 Feb 21. doi: 10.3892/ijo.2012.1381. [PubMed] [pdf]
• Campregher C, Gasche C. "Aminosalicylates." Best Pract Res Clin Gastroenterol. 2011 Aug;25(4-5):535-46. [PubMed] [pdf]
• Finsterbusch M, Khare V, Campregher C, Evstatiev R, Gasche C. "An intracytoplasmic IL-10 receptor variant permits rapid reduction in STAT3 activation." Genes Immun. 2011 Jun 9. doi: 10.1038/gene.2011.12. [PubMed] [pdf]
• Campregher C, Scharl T, Nemeth M, Honeder C, Jascur T, Boland CR, Gasche C. "The Nucleotide Composition of Microsatellites Impacts Both Replication Fidelity and Mismatch Repair in Human Colorectal Cells." Hum Mol Genet. 2010 Jul 1;19(13):2648-57. Epub 2010 Apr 26. [PubMed] [pdf]
• Campregher C, Honeder C, Chung H, Carethers JM, Gasche C. "Mesalazine Reduces Mutations in Transforming Growth Factor {beta} Receptor II and Activin Type II Receptor by Improvement of Replication Fidelity in Mononucleotide Repeats." Clin Cancer Res. 2010 Mar 2. [PubMed] [pdf]
• Campregher C, Luciani MG, Biesenbach P, Evstatiev R, Lyakhovich A, Gasche C. "The position of the amino group on the benzene ring is critical for mesalamine's improvement of replication fidelity." Inflamm Bowel Dis. 2010 Apr;16(4):576-82. [PubMed] [pdf]
• Campregher C, Luciani MG, Gasche C. "Activated Neutrophils Induce an hMSH2-dependent G2/M Checkpoint Arrest and Replication Errors at a (CA)13-repeat in Colon Epithelial Cells." Gut. 2008 Jun;57(6):780-7. Epub 2008 Feb 13.  [PubMed] [pdf]
• Luciani MG, Campregher C, Gasche C. "Aspirin blocks Proliferation in Colon Cells by inducing a G1-Arrest and Apoptosis through Activation of the Checkpoint Kinase ATM" Carcinogenesis. 2007 Oct;28(10):2207-17. Epub 2007 May 17. [PubMed] [pdf]
• Luciani MG, Campregher C, Fortune JM, Kunkel TA, Gasche C. "5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint" Gastroenterology. 2007 Jan;132(1):221-35. [PubMed] [pdf]
  

  BOOK ARTICLES: 

• "Cancer in IBD: Is there a chance for cancer prevention?" Gasche C, Campregher C, Luciani MG FALK SYMPOSIA Nr.165 (Springer) 2008
• "5-ASA and replication fidelity" Campregher C, Luciani MG, Gasche C FALK SYMPOSIA Nr.158 (Springer) 2007

• PA716ER002 "Effect of 5-ASA derivatives on oxygen scavenging in colorectal cells"

• European Journal of Clinical Investigation (link)
• International Journal of Inflammation (link)

  TEACHING EXPERIENCE:

• External lecturer at the IMC-Krems, Austria
• Lecturer at the Medical University of Vienna, Austria

  INVITED TALKS:   

• ISG Winter Meeting 2011, Killiney Castle (Ireland) "IBD and Colorectal Carcinogenesis: 5-ASA effects for Pathogenetic defects"
• Menopause Congress 2009 (A) "Curcumin und Pflanzeninhaltsstoffe – Antioxidative und antiinflammatorische Potenz"

  ORAL PRESENTATIONS:

• UEGW 2008, Vienna (A) "Mesalazine Improves Replication Fidelity at Microsatellites Irrespective of Sequence and Length of the Nucleotide Repeat"
• PhD Symposium 2008, Medical University of Vienna (A) "Activated Neutrophils (PMNs) Increase Mutations at Repetitive (CA) Sequences in Colon Epithelial Cells"
• DDW 2007, Washington DC (USA)"Activated Neutrophils (PMNs) Increase Mutations at Repetitive (CA) Sequences in Colon Epithelial Cells"
• PhD Symposium 2006, Medical University of Vienna (A) "Activated Neutrophils Cause an MLH1-independent G2/M Arrest and p53Ser15 Phosphorylation in Colorectal Cells"
• DDW 2006, Los Angeles (USA) "Activated Neutrophils Cause an MLH1-independent G2/M Arrest and p53Ser15 Phosphorylation in Colorectal Cells"
• PhD Symposium 2005, Medical University of Vienna (A) "Inflammation causes G2-M arrest and apoptosis in colorectal cells which depends on MMR proficiency"

  POSTER PRESENTATIONS:

• HGM Shanghai, 2002 "Structural and functional characterisation of the mouse genome" H. Himmelbauer, B. Greber, C. Campregher, L.C. Schalkwyk, H. Lehrach
  
• DHGB Leipzig, 2002 (D) "Chemical mutagenesis and clone library generation of mouse embryonic stem cells" B. Greber, C. Campregher, H. Lehrach, H. Himmelbauer
• Genome Sequencing & Biology, Cold Spring Harbor, 2002 (USA) "Structural and functional characterisation of the mouse genome" H. Himmelbauer, B. Greber, C. Campregher, L.C. Schalkwyk, H. Lehrach
  
• NGFN Berlin, 2002 (D) "Chemical mutagenesis and clone library generation of mouse embryonic stem cells" B. Greber, C. Campregher, H. Lehrach, H. Himmelbauer
• Tumor Invasion and Metastasis, Vienna 2005 (A) "Inflammation causes MMR-dependent G2-M arrest and apoptosis in colorectal cells" C. Campregher, G.M.Luciani, C. Gasche
• Cold Spring Harbor 2005 (USA) "NSAIDs and salicylate derivatives affect cell cycle progression in colorectal cancer cells by activating cellular checkpoint mechanisms" G.M. Luciani, C. Campregher, C.Gasche
  
• Falk Symposium 2005, Berlin (D) "Inflammation causes G2-M arrest and apoptosis in colorectal cells which depend on MMR proficiency" C. Campregher, G.M. Luciani, C. Gasche
• UEGW 2006 Berlin (D) "Aspirin Affects Cell Cycle Progression in Colorectal Cells by Activating a p53- and p21-dependent G1 Checkpoint" G.M. Luciani, C. Campregher, C. Gasche
• Falk Symposium 2007, Sevilla (ES) "Mesalazine counteracts the mutagenic effect of the intercalating agent 9-aminoacridine" C. Campregher, G.M. Luciani, C. Gasche
• DDW 2007, Washington DC (USA) "5-ASA Differentially Regulates Genes Involved in Cell Cycle Progression, DNA Methylation, and Wnt Signaling in Colon Cells." G.M. Luciani, C. Campregher, B. Tichy, J.R. Hutchins, S. Pospisilova, C. Gasche
• PhD Symposium 2007, AKH Wien (A) "Activated Neutrophils (PMNs) Increase Mutations at Repetitive (CA) Sequences in Colon Epithelial Cells" C. Campregher, G.M. Luciani, C. Gasche
• FEBS 32nd Congress in Vienna 2007 (A) "Activated Neutrophils Cause a G2/M Arrest and Mutations in Colon Epithelial Cells" C. Campregher, G.M. Luciani, C. Gasche
• DDW 2008, San Diego (CA, USA) "Mesalazine Improves Replication Fidelity at Microsatellites Irrespective of Sequence and Length of the Nucleotide Repeat" Campregher C, Honeder C, Gasche C & "Differential Effects of 5-ASA Derivatives 4-ASA, 3-ASA and N-acetyl-5-ASA on Cell Cycle and Replication Fidelity in Colon Epithelial Cells" G.M. Luciani, C. Campregher, P. Biesenbach, C. Gasche
• DDW 2009, Chicago (IL, USA) "Cytpoplasmic abundance of the mRNA stabilizing HuR protein in ulcerative colitis, Crohn's disease and in an in-vitro model of inflammation" M. Lang, C. Campregher, A. Lyakhovich, C. Gasche
• DDW 2009, Chicago (IL, USA) "The Novel Compound GWG-120817 Affects Cell Cycle Progression and Replication Fidelity in Colon Epithelial Cells" C. Campregher, C. Honeder, C. Gasche
• DDW 2009, Chicago (IL, USA) "Activated Neutrophils Induce DNA Methylation in Colon Epithelial Cells by Up-regulating de-novo DNA Methyltransferases DNMT3A and DNMT3B" C. Campregher, A. Goel, C.R. Boland, C. Gasche
• 42. ÖGGH-Jahrestagung 2009, Vienna (A) "The Novel Compound GWG-120817 Affects Cell Cycle Progression and Replication Fidelity in Colon Epithelial Cells" C. Campregher, C. Honeder, C. Gasche
• 42. ÖGGH-Jahrestagung 2009, Vienna (A) "Activated Neutrophils Induce DNA Methylation in Colon Epithelial Cells by Up-regulating de-novo DNA Methyltransferases DNMT3A and DNMT3B" C. Campregher, A. Goel, C.R. Boland, C. Gasche
• 43. ÖGGH-Jahrestagung 2010, Ried i. Innkreis (A)"The Nucleotide Composition of Microsatellites Impacts Both Replication Fidelity and Mismatch Repair in Human Colorectal Cells" C. Campregher, T. Scharl, M. Nemeth, C. Honeder, T. Jascur, C.R. Boland, C. Gasche
• UEGW 2010, Barcelona (ES) "Activated Neutrophils Lead to Increased DNA-Bound Dnmt3b and Induce Promoter Hypermethylation of RARβ, MGMT, IGSF4 and RB1 in Colon Epithelial Cells" C. Campregher, Y. Shen, J. Gasche, A. Goel, C. Gasche &
• UEGW 2010, Barcelona (ES) "Activated Neutrophils Cause Mismatch Repair Independent Increase of Frameshift Mutations and Polymerase-Beta Expression in Colon Epithelial Cells" C. Campregher, V. Khare, J. Mühlbachler, C. Gasche

  AWARDS:

• Poster of Distinction, DDW 2009 Chicago (IL)
• Friedrich-Wewalka Award 2008 of the Austrian Gastroenterological Association ÖGGH
• Poster of Distinction, DDW 2008 San Diego (CA)
• Travel Grant for Basic Scientists, UEGW 2008

  GRANTS:

• FWF P18270 Co-Investigator "Chronic Inflammation and Colorectal Carcinoma" 01.09.2005 - 31.08.2009
• FWF P24121 Co-Investigator "Colitis Ulcerosa und Mikrosatelliteninstabilität" 01.01.2012 - 31.12.2014

  OTHER ARTICLES AND PROJECTS:

• "Can Scientists Dance?" by John Bohannon (The Gonzo Scientist), Science/AAAS 2008 (full article)
• Founder of "science<>salon vienna" http://science-salon.blogspot.com/

  SOFTWARE:

           Windows, Mac OS, Unix basics, Bioinformatics basics, Office, Adobe Photoshop, Macromedia Webdesign, 
           setup and installation of computers and networks

  LANGUAGES:

           German (native), English (good)

  HOBBIES:

            Webdesign, Computer Generated Music, Art Performance (Music and Painting), 
            Climbing, Hiking, Skiing